NMDA receptor subunit-dependent modulation by conantokin-G and Ala(7)-conantokin-G
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چکیده
منابع مشابه
Determination of the solution structures of conantokin-G and conantokin-T by CD and NMR spectroscopy.
Conantokin-G and conantokin-T are two paralytic polypeptide toxins originally isolated from the venom of the fish-hunting cone snails of the genus Conus. Conantokin-G and conantokin-T are the only naturally occurring peptidic compounds which possess N-methyl-D-aspartate receptor antagonist activity, produced by a selective non-competitive antagonism of polyamine responses. They are also structu...
متن کاملEffect of Conantokin G on NMDA receptor-mediated spontaneous EPSCs in cultured cortical neurons.
Conantokin G (Con G), derived from the venom of Conus geographus, is the most characterized natural peptide antagonist targeted to N-methyl-D-aspartate (NMDA) receptors. Although Con G is known to bind to the glutamate binding site on the NR2 subunit of the receptor, it is unclear whether it can allosterically modulate the function of the receptor through the glycine binding site on the NR1 sub...
متن کاملThe Effect of Conantokin G on NMDA Receptor-Mediated Spontaneous EPSCs in Cultured Cortical Neurons
Conantokin G (Con G), derived from the venom of Conus geographus, is the most characterized natural peptide antagonist targeted to NMDA receptors. Although Con G is known to bind to the glutamate binding site on the NR2 subunit of the receptor, it is unclear whether it can allosterically modulate the function of the receptor through the glycine binding site on the NR1 subunit. The present study...
متن کاملConantokin-G Attenuates Detrimental Effects of NMDAR Hyperactivity in an Ischemic Rat Model of Stroke
The neuroprotective activity of conantokin-G (con-G), a naturally occurring antagonist of N-methyl-D-aspartate receptors (NMDAR), was neurologically and histologically compared in the core and peri-infarct regions after ischemia/reperfusion brain injury in male Sprague-Dawley rats. The contralateral regions served as robust internal controls. Intrathecal injection of con-G, post-middle carotid ...
متن کاملConantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors.
Conantokin G (Con G) is a 17-amino-acid peptide antagonist of N-methyl-D-aspartate (NMDA) receptors isolated from the venom of the marine cone snail, Conus geographus. The mechanism of action of Con G has not been well defined; both competitive and noncompetitive interactions with the NMDA-binding site have been proposed. In this study the mechanism of action and subunit selectivity of Con G wa...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2006
ISSN: 0022-3042,1471-4159
DOI: 10.1111/j.1471-4159.2005.03574.x